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Severe Alzheimer's Disease Adverse Events Leading to Discontinuation The rates of discontinuation from controlled clinical trials of donepezil hydrochloride due to adverse events for the donepezil hydrochloride patients were approximately 12% compared to 7% for placebo patients.

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These include, but are not limited to, Parkinson's disease, multi-infarct dementia, and dementia due to cerebrovascular disease.

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The Trial Comparing Cardiovascular Safety of Insulin Degludec versus Insulin Glargine in Patients with Type 2 Diabetes at High Risk of Cardiovascular Events DEVOTE is the first doubleblind CVOT with a headtohead of two basal insulins insulin degludec versus insulin glargine U100 added to usual care of T2DM patients at high CV risk.

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These are known class effects of cholinergic therapies, and often occur primarily at the beginning of treatment.

Jabbour SA, Hardy E, Sugg J, Parikh S; Study 10 Group.

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Antipsychotic prescribing in care homes before and after launch of a national dementia strategy: an observational study in English institutions over a 4year period.

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Feldman H, Gauthier S, Hecker J, Vellas B, Hux M, Xu Y, Schwam EM, Shah S, Mastey V, Donepezil MSAD Study Investigators Group.

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Our article now cites a review from 2014; there is no reason under MEDRS or any policy or guideline for citing an older review when a newer one is available.

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Antipsychotic medications have been the mainstay of psychopharmacological treatment for BPSD during the last several decades despite their overuse in the 1980s and the federal regulations implemented in the early 1990s ().

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Recommendation 1 continues that the decision to initiate a trial of therapy should be based on an individualized assessment.

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Important potential benefits included decision making, cognitive function, physical function, quality of life, safety, and caregiver burden.

Schneider believes that much of the optimism surrounding the use of cholinesterase inhibitors for behavior is based on improvements in the Neuropsychiatric Inventory Scale in earlier studies.

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Comparisons of clinical profile and changes in MMSE scores in patients with mild dementia receiving donepezil (donepezil group) and donepezil plus cilostazol (combination group).

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Early detection and diagnosis of dementia through the assessment of patient-, family-, or physician-recognized signs and symptoms, some of which may be subtle, are not considered screening and are not the focus of this recommendation.

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Because of their mechanism of action, cholinesterase inhibitors, including donepezil hydrochloride, have the potential to interfere with the activity of anticholinergic medications.

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Older patients in general, and patients with dementia in particular, are more sensitive to medication adverse effects, including anticholinergic effects, orthostatic hypotension, sedation, parkinsonism, tardive dyskinesia (TD) and cognitive impairment than younger patients with dementia or individuals without dementia.

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Progress: More work is needed on this objective; studies have been funded in this area (e.

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Andy Soileau, a Louisiana pharmacist, recently testified before state lawmakers about the issue.

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